Publications
IX Enzymatic and microbial syntheses
- Z. Luo, S. M. Swaleh, F. Theil, D. P. Curran,
Resolution of 1-(2-naphthyl)ethanol by a combination of an enzyme-catalyzed kinetic resolution with a fluorous triphasic separative reaction,
Org. Lett. 2002, 4, 2585-2587. - S. M. Swaleh, B. Hungerhoff, H. Sonnenschein, F. Theil,
Separation of enantiomers by lipase-catalyzed fluorous phase delabeling,
Tetrahedron 2002, 58, 4085-4089. - B. Hungerhoff, H. Sonnenschein, F. Theil,
Combining Lipase-Catalyzed Enantiomer-Selective Acylation with Fluorous Phase-Labeling: A New Method for the Resolution of Racemic Alcohols,
J. Org. Chem. 2002, 67, 1781-1785. - B. Hungerhoff, H. Sonnenschein, F. Theil,
Separation of Enantiomers by Extraction Based on Lipase-Catalyzed Enantiomer-Selective Fluorous-Phase Labeling,
Angew. Chem. 2001, 113, 2550-2552; Angew. Chem. Int. Ed. 2001, 40, 2492-2494. - K. Lemke, M. Lemke, F. Theil,
A Three-Dimensional Predictive Active Site Model for Lipase from Pseudomonas cepacia,
J. Org. Chem. 1997, 62, 6268-6273. - K. Lemke, S. Ballschuh, A. Kunath, F. Theil,
An Improved Procedure for the Lipase-catalysed Kinetic Resolution of endo-endo-cis-bicyclo[3.3.0]octane-2,6-diol – Synthesis of Potential C2-symmetric Enantiomerically Pure Bidentate Auxiliaries,
Tetrahedron: Asymmetry 1997, 8, 2051-2055. - B. Henkel, A. Kunath, H. Schick,
Enzymes in Organic Synthesis, 27.
Enzyme-Catalyzed Synthesis of (5R,6S)-6-Acetoxyalkan-5-olides – Homologues of the Mosquito Oviposition Attractant Pheromone,
J. Prakt. Chem. 1997, 339, 434-440. - F. Theil, S. Ballschuh,
Chemoenzymatic Synthesis of Both Enantiomers of Cispentacin,
Tetrahedron: Asymmetry 1996, 7, 3565-3572. - F. Theil, H. Sonnenschein, T. Kreher,
Lipase-catalysed Resolution of 3,3′-Bi-indolizines: The First Preparative Access to Enantiomerically Pure Samples,
Tetrahedron: Asymmetry 1996, 7, 3365-3370. - F. Theil,
Enzymatische Hydrolyse von Nitrilen,
Nova Acta Leopoldina Suppl. 14, 1996, 143-150. - K. Lemke, F. Theil, A. Kunath, H. Schick,
Lipase-catalysed Kinetic Resolution of Phenylethane-1,2-diol by Sequential Transesterification – the Influence of the Solvent,
Tetrahedron: Asymmetry 1996, 7, 971-974. - F. Theil, S. Ballschuh, M. von Janta-Lipinski, R. A. Johnson,
Chemoenzymatic Synthesis of Carbocyclic Nucleoside Analogues,
J. Chem. Soc. Perkin Trans. 1, 1996, 255-258. - R. Ozegowski, A. Kunath, H. Schick,
Enzymes in Organic Synthesis, 26.
Synthesis of Enantiomerically Enriched 2,3- and 3,4-Dimethylpentan-5-olides via Lipase-catalyzed Regio- and Enantioselective Alcoholysis of cis– and trans-2,3-Dimethylpentanedioic Anhydrides,
Liebigs Ann. 1996, 1443-1448. - F. Theil, K. Lemke, S. Ballschuh, A. Kunath, H. Schick,
Lipase-catalysed Resolution of 3-(Aryloxy)-1,2-propanediol Derivatives – Towards an Improved Active Site Model of Pseudomonas cepacia Lipase (Amano PS),
Tetrahedron: Asymmetry 1995, 6, 1323-1344. - R. Ozegowski, A. Kunath, H. Schick,
Enzymes in Organic Synthesis, 25.
The Lipase-Catalyzed Sequential Esterification of (±)-2-Methylbutanedioic Anhydride – A Biocatalytical Access to an Enantiomerically Pure 1-Monoester of (S)-2-Methylbutanedioic Acid,
Liebigs Ann. 1995, 1699-1702. - R. Ozegowski, A. Kunath, H. Schick,
Enzymes in Organic Synthesis, 24.
The Different Behaviour of syn– and anti-2,3-Dimethylbutanedioic Anhydride in the Lipase-catalyzed Enantioselective Alcoholysis,
Tetrahedron: Asymmetry 1995, 6, 1191-1194. - B. Henkel, A. Kunath, H. Schick,
Enzymes in Organic Synthesis, 23.
Chemo-enzymatic Synthesis of (5R,6S)-6-Acetoxyhexadecan-5-olide – the Major Component of the Mosquito Oviposition Attractant Pheromone,
Liebigs Ann. 1995, 921-923. - A. Kerridge, J. S. Parratt, S. M. Roberts, F. Theil, N. J. Turner, A. J. Willets,
Microbial Hydrolysis of Glutaronitrile Derivatives with Brevibacterium sp. R312,
Bioorg. Med. Chem. 1994, 2, 447-455. - F. Theil, A. Kunath, M. Ramm, T. Reiher, H. Schick,
Double Enantioselective Transesterification of Racemic Carboxylic Esters and Cyclic meso-Diols by Lipase Catalysis,
J. Chem. Soc. Perkin Trans. 1, 1994, 1509-1516. - J. Weidner, F. Theil, H. Schick,
Kinetic Resolution of (1RS,2SR)-2-(Hydroxymethyl)cyclopentanol by a Biocatalytic Transesterification Using Lipase PS,
Tetrahedron: Asymmetry 1994, 5, 751-754. - F. Theil, J. Weidner, A. Kunath, H. Schick,
Kinetic Resolution of Acyclic 1,2-Diols Using a Sequential Lipase-Catalyzed Transesterification in Organic Solvents,
J. Org. Chem. 1994, 59, 388-393. - R. Ozegowski, A. Kunath, H. Schick,
Enzymes in Organic Synthesis, 21.
Lipase-Catalyzed Conversion of (±)-2-Methylglutaric Anhydride into (S)-2-Methyl- and (R)-4-Methyl δ-Valerolactone via a Regio- and Enantioselective Sequential Esterification,
Liebigs Ann. Chem. 1994, 1019-1023. - R. Ozegowski, A. Kunath, H. Schick,
Enzymes in Organic Synthesis, 22.
The Sequential Enzyme-catalyzed Esterification of a Prochiral Dicarboxylic Anhydride – An Improved Access to 1-(2-Methylpropyl) 5-Hydrogen (2R,4S)-2,4-Dimethylpentanedioate,
J. Prakt. Chem. 1994, 336, 544-546. - R. Ozegowski, A. Kunath, H. Schick,
Enzymes in Organic Synthesis, 19.
The Enzyme-catalyzed Sequential Esterification of (±)-anti-2,4-Dimethylglutaric Anhydride. – An Efficient Route to Enantiomerically enriched Mono- and Diesters of anti-2,4-Dimethylglutaric Acid,
Liebigs Ann. Chem. 1994, 215-217. - B. Henkel, A. Kunath, H. Schick,
Enzymes in Organic Synthesis, 20.
Synthesis of (3R,5S)-3-Hydroxy-7-phenyl-6-heptyn-5-olide by an Enantioselective Enzyme-catalyzed Lactonization of a Racemic 3,5-Dihydroxy Ester,
Tetrahedron: Asymmetry 1994, 5, 17-18. - F. Theil, F. Björkling,
Specificity of Candida antarctica Lipase B (SP 435) in the Presence of Lipase A in a Double Enantioselective Transesterification,
Biotechnol. Lett. 1993, 15, 605-608. - F. Theil, J. Weidner, S. Ballschuh, A. Kunath, H. Schick,
Kinetic Resolution of Aliphatic 1,2-Diols by a Lipase-Catalyzed Sequential Acetylation,
Tetrahedron Lett. 1993, 34, 305-306. - H. Schick, E. Schrötter, M. Szymanowski, A. Knoll,
Enzymes in Organic Synthesis, 13.
Synthesis of Alkyl (±)-2,3-Di-O-acylglycerates and Attempts Directed to Their Conversion into Alkyl (R)-2,3-Di-O-acylglycerates by Enzyme-catalyzed Enantioselective Deacylation Reactions,
J. Prakt. Chem./Chemiker-Zeitung 1993, 335, 555-560. - R. Ozegowski, A. Kunath, H. Schick,
Enzymes in Organic Synthesis, 18.
Lipase-catalyzed Asymmetric Alcoholysis of 3-Substituted Pentanedioic Anhydrides,
Liebigs Ann. Chem. 1993, 805-808. - H. Schick, M. Szymanowski,
Enzymes in Organic Synthesis, 12.
Synthesis of (±)-2-O-Benzylglyceric Acid Derivatives for Studies on Enzyme-catalyzed Acylation and Deacylation Reactions,
J. Prakt. Chem. 1993, 335, 377-380. - R. Ozegowski, A. Kunath, H. Schick,
Enzymes in Organic Synthesis. 17.
Synthesis of 2,4-Dimethylglutaric Acid Mono Esters via Enzyme-catalyzed Asymmetric Alcoholysis of meso-2,4-Dimethylglutaric Anhydride,
Tetrahedron: Asymmetry 1993, 4, 695-698. - B. Henkel, A. Kunath, H. Schick,
Enzymes in Organic Synthesis. 16.
Enzyme-catalyzed Lactonization of Methyl (±)-(E)-3,5-Dihydroxy-7-phenyl-6-heptenoates. – A Comparison of the Behaviour of syn– and anti-Compounds,
Tetrahedron: Asymmetry 1993, 4, 153-156. - H. Schick, E. Schrötter, M. Szymanowski, A. Knoll,
Enzymes in Organic Synthesis, 15.
Synthesis of Methyl (S)-(-)-2,3-O-Isopropylideneglycerate Through Enantioselective Enzyme-catalyzed Hydrolysis of Methyl (±)-2,3-O-Isopropylideneglycerate,
Liebigs Ann. Chem. 1993, 101-103. - F. Theil, H. Schick,
Enantioselective hydrolysis of cyclopentene-1,4-diacetate using a lipase,
In: Preparative Biotransformations, S. M. Roberts, K. Wiggins, G. Casy (eds.), 1.:5.6, Wiley, 1992. - F. Theil, H. Schick,
Lipase catalysed regioselective acetylation of ethyl α-D-mannopyranoside using pancreatin,
In: Preparative Biotransformations, S. M. Roberts, K. Wiggins, G. Casy (eds.), 1.:11.1, Wiley, 1992. - F. Theil, H. Schick,
Lipase catalysed esterification of cis-cyclopentene-1,4-diol,
In: Preparative Biotransformations, S. M. Roberts, K. Wiggins, G. Casy (eds.), 1:9.1, Wiley, 1992. - F. Theil, A. Kunath, H. Schick,
“Double Enantioselection” by a Lipase-catalyzed Transesterification of a meso-Diol with a Racemic Carboxylic Ester,
Tetrahedron Lett. 1992, 33, 3457-3460. - B. Henkel, A. Kunath, H. Schick,
Enzymes in Organic Synthesis, 11.
The Enantioselective Lactonization of Methyl 3,5-Dihydroxyalkanoates – An Access to (3R,5S,6E)-3-Hydroxy-7-phenyl-6-hepten-5-olide by Enzyme-catalyzed Kinetic Resolution in Organic Solvents,
Liebigs Ann. Chem. 1992, 809-811. - E. Schrötter, J. Weidner, H. Schick,
Synthesis of an Enantiomerically Pure Sterol Side Chain Precursor by Enantioselective Reduction of 1,3-Dihydroxy-3-methyl-2-butanone with Baker’s Yeast,
Liebigs Ann. Chem. 1991, 397-398. - J. Weidner, F. Theil, A. Kunath, H. Schick,
Synthesis of Enantiomerically Pure Prostaglandin Intermediates by Enzymatic Transesterification of (1S*,5R*,6R*,7R*)-(±)-7-Hydroxy-6-hydroxymethyl-2-oxabicyclo[3.3.0]octan-3-one,
Liebigs Ann. Chem. 1991, 1301-1303. - F. Theil, S. Ballschuh, A. Kunath, H. Schick,
Kinetic Resolution of rac-3-(2-Methylphenoxy)propane-1,2-diol (Mephenesin) by Sequential Lipase-Catalyzed Transesterification,
Tetrahedron: Asymmetry 1991, 2, 1031-1034. - F. Theil, H. Schick, G. Winter, G. Reck,
Lipase-Catalyzed Transesterification of meso-Cyclopentane Diols,
Tetrahedron 1991, 47, 7569-7582. - F. Theil, H. Schick, D. Weichert, K. Tannenberger, G. Klappach,
Enzyme-catalyzed Synthesis of (1S,4R)-(-)-4-Hydroxycyclopent-2-enyl Acetate and its (+)-Antipode – an Improved Procedure Using Lipase from Mucor sp.,
J. Prakt. Chem. 1991, 333, 497-499. - A. Knoll, M. Böhme, S. Merker, G. Fabian, B. Häfner, F. Theil,
Enantioselektive Synthese von (1S,4R)-4-Hydroxycyclopent-2-enylacetat durch enzymkatalysierte Veresterung von cis-Cyclopent-2-en-1,4-diol mit Acetanhydrid. Gaschromatographische Untersuchungen des Reaktionsmechanismus,
Chimia 1991, 45, 195-198. - F. Theil, H. Schick,
An Improved Procedure for the Regioselective Acetylation of Monosaccharide Derivatives by Pancreatin-Catalyzed Transesterification in Organic Solvents,
Synthesis 1991, 533-535. - F. Theil, H. Schick, M. A. Lapitskaya, K. K. Pivnitsky,
Investigation of the Pancreatin-Catalyzed Acylation of cis-Cyclopent-2-ene-1,4-diol with Various Trichloroethyl and Vinyl Alkanoates,
Liebigs Ann. Chem. 1991, 195-200. - M. A. Djadchenko, K. K. Pivnitsky, F. Theil, H. Schick,
Enzymes in Organic Synthesis Part 3.
Synthesis of Enantiomerically Pure Prostaglandin Intermediates by Enzyme-catalyzed Transesterification of (1SR,2RS,5SR,6RS)-Bicyclo[3.3.0]octane-2,6-diol with Trichloroethyl Acetate in an Organic Solvent,
J. Chem. Soc. Perkin Trans. 1, 1989, 2001-2002. - F. Theil, H. Schick, P. Nedkov, M. Böhme, B. Häfner, S. Schwarz,
Synthesis of Enantiomerically Pure Prostaglandin Intermediates by Enzymatic Hydrolysis of (1SR,5RS,6RS,7RS)-7-Acetoxy-6-acetoxymethyl-2-oxa-bicyclo[3.3.0]octan-3-one,
J. Prakt. Chem. 1988, 330, 893-899. - F. Theil, S. Ballschuh, H. Schick, M. Haupt, B. Häfner, S. Schwarz,
Synthesis of (1S,4R)-(-)-4-Hydroxy-2-cyclopentenyl Acetate by a Highly Enantioselective Enzyme-catalyzed Transesterification in Organic Solvents,
Synthesis 1988, 540-541. - S. Schwarz, G. Truckenbrodt, H. Schick, J. Depner,
Mikrobielle Transformation von Chlorheptan-2-on; Vorläufige Ergebnisse zur Darstellung eines chiralen Phosphoniumsalzes für Prostaglandinsynthesen,
Z. Chem. 1982, 22, 187-188. - S. Schwarz, G. Truckenbrodt, M. Meyer, R. Zepter, G. Weber, C. Carl, M. Wentzke, H. Schick, H.-P. Welzel,
Mikrobielle Reduktion 2,2-disubstituierter Cyclopentan-1,3-dione. Darstellung chiraler Cyclopentanderivate für die Synthese von 8-Methylprostaglandinen,
J. Prakt. Chem. 1981, 323, 729-736.